Spawns a pool of black creep beneath Isaac The effect triggers again 30 seconds after use and again 60 seconds after use I'm excited!!! - Speeds up all enemies for the rest of the room. Slows all enemies for the rest of the current room Unlocked from the 'Dedication' achievement (participate in 31 dailies in a row) Horf! - When used, shoots an Ipecac explosive shot. Unlocked from the 'Once more with the feeling!' achievement (complete a victory lap, defeating the lamb boss) Gulp! - When used will consume your current trinket, destroying it and giving you its effect permanently. Unlocked from the 'Sin Collector' achievement (collect every Bestiary entry) Unlocked from Challenge #25 - Have a Heartįeels like I'm walking on sunshine! - Turns Isaac invincible for a few seconds (similar to Unicorn Stump).

? - Gives the curse of the maze effect for the current floor. Happens a total of 3 times over 30 seconds Retro Vision - Pixelates the screen for a few seconds, obscuring your vision.

Similar to Explosive Diarrhea but with poop Re-Lax - Causes Isaac to spawn poops behind him while he walks for a few seconds. Power Pill - Gives you invulnerability and the ability to damage enemies for a short while (similar to The Gamekid effect) Unlocked from Challenge #24 - PAY TO PLAY Percs - Causes Isaac to only take half a heart of damage from all sources for the current room (The Wafer effect). One makes you larger - Increases Isaac's size, but does not affect the size of his hitbox One makes you smaller - Reduces Isaac's size and hitbox size If there are no enemies this pill spawns 1-3 blue spiders instead

Infested? - Spawns one blue attack spider for every enemy in the room. Infested! - Destroys all poops in the room and spawns a blue attack spider on every destroyed poop Unlocked from Challenge #24 - PAY TO PLAYįriends till the end - Spawns three friendly blue attack flies Lemon Party - Spawns a large yellow pool on the floor around you, damaging enemies which walk in itĪddicted - Causes you to take a full heart of damage for all sources for the current room. I found pills - Changes the appearance of Isaac's face for the current room (Cosmetic change only) I can see forever - Opens secret room and super secret room entrances on the current floor Hematemesis - Empties all but one red heart container and spawns 1-4 red hearts on the floor If you have 1 or less heart containers, this pill becomes Health Up Can be negated with Black Candleīad Gas - Isaac farts, poisoning enemies around himīombs are key - Switches number of bombs and keysĮxplosive Diarrhea - Spawns five live troll bombs behind Isaac, one per secondįull Health - Restores all your empty red heart containers Can be used with Placebo to generate infinite batteriesĪmnesia - Hides the floor map for the rest of the current floor (same as curse of the lost). 48 Hour Energy - Fully recharges your active item and drops 1-2 battery pickups.

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